124997-75-7 Usage
Description
(R)-3'-Hydroxy Warfarin, also known as the R-enantiomer of the 3'-hydroxyl metabolite of Warfarin, is a significant compound derived from the metabolism of the anticoagulant drug Warfarin. It possesses unique stereochemical properties and is characterized by its distinct biological activities and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
(R)-3'-Hydroxy Warfarin is used as an active pharmaceutical ingredient for its potential therapeutic effects. It is particularly relevant in the development of novel anticoagulant drugs, as it may exhibit different pharmacological properties compared to the parent compound, Warfarin. This enantiomer could be utilized to improve the safety and efficacy of anticoagulant medications, reducing the risk of bleeding and other side effects associated with the racemic mixture.
Used in Research and Development:
(R)-3'-Hydroxy Warfarin serves as a valuable research tool for understanding the stereoselective metabolism and pharmacological actions of Warfarin. It can be employed in various in vitro and in vivo studies to investigate the mechanisms of action, receptor binding, and potential drug-drug interactions. This knowledge can contribute to the development of more selective and safer anticoagulant therapies.
Used in Drug Metabolism Studies:
As a metabolite of Warfarin, (R)-3'-Hydroxy Warfarin is used in drug metabolism research to explore the metabolic pathways and enzymes involved in the biotransformation of the parent drug. This information can be crucial for predicting drug-drug interactions, understanding the role of genetic polymorphisms in drug response, and optimizing drug dosing regimens.
Used in Quality Control and Analytical Methods:
(R)-3'-Hydroxy Warfarin can be utilized as a reference compound in the development and validation of analytical methods for the quantification of Warfarin and its metabolites in biological samples. This is essential for monitoring drug levels in patients receiving anticoagulant therapy, ensuring optimal therapeutic outcomes and minimizing the risk of adverse effects.
Check Digit Verification of cas no
The CAS Registry Mumber 124997-75-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,9,9 and 7 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 124997-75:
(8*1)+(7*2)+(6*4)+(5*9)+(4*9)+(3*7)+(2*7)+(1*5)=167
167 % 10 = 7
So 124997-75-7 is a valid CAS Registry Number.
124997-75-7Relevant articles and documents
Organocatalytic enantioselective michael addition of 4-hydroxycoumarin to α,β-unsaturated ketones: a simple synthesis of warfarin
Dong, Zhenhua,Wang, Lijia,Chen, Xiaohong,Liu, Xiaohua,Lin, Lili,Feng, Xiaoming
experimental part, p. 5192 - 5197 (2010/01/11)
A type of C2-symmetric secondary amine amide catalysts were developed for the asymmetric Michael addition of Ahydroxycoumarin to α,ss-unsaturated ketones. A series of important biologically and pharmaceutically active compounds were obtained in
