125-45-1 Usage
Originator
Azatepa,ZYF Pharm Chemical
Uses
Antineoplastic.
Manufacturing Process
N-Ethyl-N-(1,3,4-thiadiazol-2-yl)amidophosphoryl chloride is prepared by
refluxing 16.4 parts of 2-ethylamino-1,3,4-thiadiazole hydrochloride with 84
parts of phosphorus oxychloride for 6 h and then removing the excess
phosphorus oxychloride by distillation under reduced pressure. The residual oil
is washed with cold petroleum ether, dried and dissolved in 310 parts of dry
benzene.
The solution of N-ethyl-N-(1,3,4-thiadiazol-2-yl)amidophosphoryl chloride is
added slowly at 10°C to a mixture of 9.5 parts of ethylenimine, 30.3 parts of
triethylamine, and 44 parts of warm dry benzene. Agitation is continued for 2
h without cooling after which the triethylamine hydrochloride is filtered off.
The benzene is distilled from the filtrate under reduced pressure, and the
N,N'-diethylene-N''-ethyl-(N'-(1,3,4-thiadiazo-2-yl)phosphoramide is
recrystallized from hexane, melting point 95°-96°C.
Therapeutic Function
Antineoplastic
Check Digit Verification of cas no
The CAS Registry Mumber 125-45-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 125-45:
(5*1)+(4*2)+(3*5)+(2*4)+(1*5)=41
41 % 10 = 1
So 125-45-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H14N5OPS/c1-2-13(8-10-9-7-16-8)15(14,11-3-4-11)12-5-6-12/h7H,2-6H2,1H3
