125-69-9 Usage
Description
Dextromethorphan Hydrobromide is a widely used pharmaceutical compound that serves as a central nervous system antitussive, effectively suppressing coughs. It is commonly found in over-the-counter (OTC) cough and cold medications due to its effectiveness in relieving cough symptoms.
Uses
Used in Pharmaceutical Industry:
Dextromethorphan Hydrobromide is used as an active ingredient for cough and cold preparations, specifically as an antitussive. It is effective in suppressing coughs by acting on the cough center in the brain, providing relief from cough symptoms.
Used in Over-the-Counter (OTC) Cough Medicine:
Dextromethorphan Hydrobromide is used as a key component in OTC cough medicines, making it one of the most popular ingredients in these products. It is known for its effectiveness in treating coughs and is often combined with other ingredients to address various cold and cough-related symptoms.
Used in Antitussive Applications:
As a central nervous system antitussive, Dextromethorphan Hydrobromide is used to suppress coughs by inhibiting the cough reflex. It is particularly useful in treating dry, non-productive coughs that do not require the expulsion of mucus.
Used as a Pharmaceutical Raw Material:
Dextromethorphan Hydrobromide is also used as a pharmaceutical raw material, which can be added to other preparations to help treat pain and a variety of other disturbances. Its versatility makes it a valuable component in the development of new medications.
Brand Names:
Some well-known brand names that contain Dextromethorphan Hydrobromide include Benylin DM (Parke-Davis), Dextromethorphan Hydrobromide OROS Tablets (Ciba-Geigy), Drixoral Cough (Schering-Plough HealthCare), PediaCare 1 (McNeil Consumer), Romilar (Hoffmann-LaRoche-International), and St. Joseph Cough Syrup (Schering-Plough HealthCare).
Originator
Symptom 1 ,Parke Davis,US,1977
Manufacturing Process
The methylation of 51.4 parts by weight of D,L-3-hydroxy-N-methylmorphinan is carried out with a methylating solution obtained from 51.5 parts
by weight of phenyl-trimethylammonium-chloride. The D,L-3-methoxy-Nmethyl-morphinan is isolated in the form of its hydrobromide, which melts
with 1 mol of water at 92°-94°C,without water at 239°-240°C. The base
isolated from the aqueous solution by means of sodium carbonate melts at
81°-83°C.27.1 parts by weight of D,L-3-methoxy-N-methyl-morphinan base are
dissolved with 15.0 parts by weight of D-tartaric acid in 150 parts by volume
of hot alcohol. The solution is cooled and seeded with (+)-3-methoxy-Nmethyl-morphinan-tartrate.The (+)-form which is difficultly soluble in alcohol
separates, is filtered by suction and washed with a little alcohol.[The (-)-form may be crystallized from the residue obtained by concentrating
the mother liquor, separating therefrom as much as possible of the (+)-form
and adding acetone].The (+)-3-methoxy-N-methyl-morphinan-tartrate melts with 1 mol of water at
195°-196°C [α]D20 =+30.6° (c = 1.5 in water). The (+) base melting at
108°-109°C may be obtained from the tartrate by means of sodium
carbonate. The corresponding hydrobromide melts at 122°-124°C [α]D20
=+27.6° (c = 1.5 in water).
Therapeutic Function
Antitussive
Check Digit Verification of cas no
The CAS Registry Mumber 125-69-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 5 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 125-69:
(5*1)+(4*2)+(3*5)+(2*6)+(1*9)=49
49 % 10 = 9
So 125-69-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/m1../s1