125-86-0 Usage
Description
Caramiphen hydrogen edisilate, also known as Bis[1-(carbo-β-diethylaminoethoxy)-1-phenylcyclopentane]ethanedisulfonate, is an anticholinergic and antiglutamatergic drug with a wide range of applications in the medical field. It is characterized by its ability to block the action of acetylcholine and glutamate, neurotransmitters that play a crucial role in various physiological processes. This unique property makes it a versatile compound with potential therapeutic uses.
Uses
Used in Pharmaceutical Industry:
Caramiphen hydrogen edisilate is used as an anticholinergic and antiglutamatergic drug for its ability to block the action of acetylcholine and glutamate, which can help in managing various conditions related to an overactive nervous system.
Used in Antidote Development:
Caramiphen hydrogen edisilate is used as an antidote against organophosphate poisoning, a severe and potentially life-threatening condition caused by exposure to certain types of insecticides and nerve agents. Its anticholinergic and antiglutamatergic properties help counteract the toxic effects of organophosphates by blocking the overstimulation of the nervous system.
Originator
Panparnit,Geigy,US,1949
Manufacturing Process
20.8 parts of 1-phenylcyclopentyl-1-carboxylic acid chloride, obtained from
the acid (cf. Am. Soc. 1934, 56, 715) by means of thionyl chloride, are
dissolved in 250 parts by volume of absolute ether, then, while stirring and
cooling with a mixture of common salt and ice a solution of 12 parts of
diethylaminoethanol in 50 parts by volume of absolute ether is allowed to
drop there into, the temperature being maintained below 0°C, whereupon
stirring is continued during 2 hours at room temperature. The whole is then
twice shaken out with water and once with diluted hydrochloric acid, the
combined aqueous solutions are made alkaline with a potassium carbonate
solution and shaken out with ether. The ethereal solution is washed with
water, dried over potassium carbonate and the solvent is distilled off. The base
boils at a pressure of 0.07 mm at 112°C to 115°C.The base may then be converted to the hydrochloride or to the
ethanedisulfonic acid salt (edisylate).
Therapeutic Function
Antitussive
Check Digit Verification of cas no
The CAS Registry Mumber 125-86-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 5 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 125-86:
(5*1)+(4*2)+(3*5)+(2*8)+(1*6)=50
50 % 10 = 0
So 125-86-0 is a valid CAS Registry Number.
InChI:InChI=1/2C18H27NO2.C2H6O6S2/c2*1-3-19(4-2)14-15-21-17(20)18(12-8-9-13-18)16-10-6-5-7-11-16;3-9(4,5)1-2-10(6,7)8/h2*5-7,10-11H,3-4,8-9,12-15H2,1-2H3;1-2H2,(H,3,4,5)(H,6,7,8)
