125036-76-2Relevant articles and documents
Phenoxyacetic acid derivatives, pharmaceutical compositions and methods
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, (2008/06/13)
Novel phenoxyacetic acid derivative of the formula: STR1 wherein R is a substituted or unsubstituted phenyl group, naphthyl group or a sulfur-containing 5-membered hetero-monocyclic group, R1, R2, R3 and R4 are hydrogen atom, a lower alkyl group, a phenyl-lower alkyl group or phenyl group, R5 is hydrogen atom or a lower alkyl group, R6 is carboxyl group, a protected carboxyl group, hydroxy group or a di(lower alkyl)-amino group, Ring A is a substituted or unsubstituted phenylene group, m is 0 or 1 and n is an integer 0 to 5, provided that, when m is 0, (1) at least either one of R1 to R4 is or/are a phenyl-lower alkyl group or phenyl group, (2) at least either one of R1 to R4 is or/are a lower alkyl group, and R6 is hydroxy group, or (3) all of R1 to R4 are hydrogen atom, and Ring A is a substituted phenylene group, or a pharmaceutically acceptable salt thereof are disclosed. Said derivative (I) and a pharmaceutically acceptable salt thereof have a potent platelet aggregation-inhibiting activity.
