1250364-28-3Relevant articles and documents
Design, synthesis and anticholinesterase activity of a novel series of 1-benzyl-4-((6-alkoxy-3-oxobenzofuran-2(3H)-ylidene) methyl) pyridinium derivatives
Nadri, Hamid,Pirali-Hamedani, Morteza,Shekarchi, Maryam,Abdollahi, Mohammad,Sheibani, Vahid,Amanlou, Massoud,Shafiee, Abbas,Foroumadi, Alireza
experimental part, p. 6360 - 6366 (2010/10/01)
A novel series of benzofuranone-ylidene-methyl benzylpyridinium derivatives (6a-u) were synthesized as acetylcholinesterase inhibitors. The anticholinesterase activity of synthesized compounds was measured using colorimetric Ellman's method. It was revealed that some synthesized compounds exhibited high anticholinesterase activity, among them compound 6b was the most active compound (IC50 = 10 ± 6.87 nM).