125058-99-3

Basic information

• Product Name: N-<2-(3-fluorophenyl)ethyl>acetamide
• Synonyms: N-<2-(3-fluorophenyl)ethyl>acetamide
• CAS NO: 125058-99-3
• Molecular Weight: 181.21
• Mol File: 125058-99-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-<2-(3-fluorophenyl)ethyl>acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-<2-(3-fluorophenyl)ethyl>acetamide(125058-99-3)
• EPA Substance Registry System: N-<2-(3-fluorophenyl)ethyl>acetamide(125058-99-3)

Safety Data

• Hazardous Substances Data: 125058-99-3(Hazardous Substances Data)

Upstream product

• 404-70-6 2-(3-Fluorophenyl)ethylamine 
• 75-36-5 acetyl chloride 
• 140-11-4 Benzyl acetate 

Relevant articles and documents

PYRAZOLOPYRIMIDINES HAVING ACTIVITY AGAINST THE RESPIRATORY SYNCYTIAL VIRUS (RSV)

The invention concerns compounds having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and

Pyrimidine derivatives and processes for the preparation thereof

The present invention relates to novel pyrimidine derivatives and pharmaceutically acceptable non-toxic salts thereof which possess an excellent inhibitory activity against gastric acid secretion, a pharmaceutical composition containing the same as an active ingredient, and a process for the preparation thereof.

Design and Synthesis of New Naphthalenic Derivatives as Ligands for 2-Iodomelatonin Binding Sites

New melatonin-like agents were designed from the frameworks of 2,5-dimethoxyphenethylamine, an important structural moiety for the 5-HT receptor, and (2-methoxynaphthyl)ethylamine.The compounds were synthesized by classical methods and evaluated in binding assays with chicken brain membranes using 2-(125I>iodomelatonin as the radioligand.Preliminary studies on the series of N-acyl-disubstituted phenethylamines showed the favorable role of the methoxy group in the ortho position of the side chain on the affinity for the receptor ( Ki = 8 +/- 0.2 nM ) for N-propionamide (3o).This effect was confirmed in a series of the naphthalene derivatives, a bioisosteric moiety of the indole ring, and several potent ligands for melatonin binding sites were prepared such as N-propionamide (4b) ( Ki = 0.67 +/- 0.05 nM ) and N-cyclopropylformamide (Ki = 0.05 +/- 0.004 nM ( (4k).Structure-activity relationships are discussed with regard to melatonin and bioisosteric naphthalenic compound 2.The Ki value for 4b was affected to a similar extent to that of melatonin by GTP-γ-S or Mn2+ in competition experiments, suggesting an agonist profile for this compound.