1250773-62-6

Basic information

• Product Name: 2,2-difluoro-2-(2-methoxyphenyl)acetic acid
• Synonyms: 2,2-difluoro-2-(2-methoxyphenyl)acetic acid
• CAS NO: 1250773-62-6
• Molecular Weight: 202.158
• Mol File: 1250773-62-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 310.9±42.0 °C(Predicted)
• Density: 1.324±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2,2-difluoro-2-(2-methoxyphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-difluoro-2-(2-methoxyphenyl)acetic acid(1250773-62-6)
• EPA Substance Registry System: 2,2-difluoro-2-(2-methoxyphenyl)acetic acid(1250773-62-6)

Safety Data

• Hazardous Substances Data: 1250773-62-6(Hazardous Substances Data)

Usage

Derivative of acetic acid

It is a modified version of acetic acid This means that the compound is structurally related to acetic acid, from which it is derived by making certain modifications to the chemical structure.

Two fluorine atoms

The presence of fluorine atoms in the molecule This contributes to the compound's unique reactivity and properties, as fluorine is a highly electronegative element.

2-Methoxyphenyl group

A methoxy group (-OCH3) is attached to a phenyl ring (a six-carbon ring structure) in the molecule This functional group imparts specific characteristics to the compound, such as solubility and reactivity.

Used in synthesis of pharmaceuticals and agrochemicals

It serves as a building block for various organic molecules This highlights the compound's importance in the creation of new drugs and chemicals for agriculture.

Potential uses in medicinal chemistry and drug discovery

The compound may have applications in the development of new therapeutic agents This indicates that researchers are interested in exploring the compound's properties and potential applications in the field of medicine.

Valuable tool for researchers

Its unique structure and properties make it useful in organic and medicinal chemistry This emphasizes the compound's significance in advancing scientific knowledge and understanding in these fields.

Upstream product

• 529-28-2 4-iodoanisol 
• 1150164-80-9 2,2-difluoro-2-(2-methoxyphenyl)acetic acid ethyl ester 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 395-48-2 1-methoxy-2-(trifluoromethyl)benzene 

Relevant articles and documents

Synthetic method of aromatic ring group or aromatic heterocyclic tetrazole

The synthetic method comprises the following steps: (1) reacting 1.0 eq of ArI or HArI with 1.2 eq of ethyl 2, 2-difluoroacetate in the presence of DMSO as a solvent and 4.0 eq of Cu under the protection of nitrogen at 30 DEG C and 50 DEG C, and purifying to obtain a first intermediate compound; (2) dissolving 1.0 eq of the first intermediate compound in a mixed solvent of THF and water, adding 2.0 eq of LiOH, reacting at room temperature for 2 hours, spin-drying the solvent, adding HCl until the pH value is equal to 3, and filtering to obtain a second intermediate compound; and (3) reacting 1.0 eq of the second intermediate compound with 2.0 eq of diphenyl azide phosphate in the presence of 2.5 eq of triethylamine by taking tert-butyl alcohol as a solvent to generate aromatic ring group or aromatic heterocyclic tetrazole. The invention provides a novel synthetic method of aromatic ring group or aromatic heterocyclic tetrazole, wherein a target compound can be more conveniently obtained, and reagents participating in the reaction are low in toxicity, mild in reaction condition, simple and safe in aftertreatment, good in product quality and suitable for large-scale production.

Easy Access to Difluoromethylene-Containing Arene Analogues through Palladium-Catalysed C–H Olefination

An efficient palladium-catalysed ortho-C–H olefination of α,α-difluorophenylacetic acid derivatives using 8-aminoquinoline as a bidentate directing group has been developed. A range of olefinated arenes can thus be synthesized in a concise way. This reaction provides an easy and straightforward route to a panel of difluoromethylated arene analogues in moderate to good yields, with a satisfactory tolerance of common functional groups. Transformation of the products into a variety of other difluoromethylene-containing compounds demonstrates the utility of this method.

Catalytic decarboxylative fluorination for the synthesis of Tri- and difluoromethyl arenes

Treatment of readily available α,α-difluoro- and α-fluoroarylacetic acids with Selectfluor under Ag(I) catalysis led to decarboxylative fluorination. This operationally simple reaction gave access to tri- and difluoromethylarenes applying a late-stage fluorination strategy. Translation to [18F]labeling is demonstrated using [ 18F]Selectfluor bis(triflate), a reagent affording [ 18F]tri- and [18F]difluoromethylarenes not within reach with [18F]F2.