1250829-43-6

Basic information

• Product Name: N-(4-methylbenzyl)-N-propargyl-1H-indole-2-carboxamide
• Synonyms: N-(4-methylbenzyl)-N-propargyl-1H-indole-2-carboxamide
• CAS NO: 1250829-43-6
• Molecular Weight: 302.376
• Mol File: 1250829-43-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-methylbenzyl)-N-propargyl-1H-indole-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methylbenzyl)-N-propargyl-1H-indole-2-carboxamide(1250829-43-6)
• EPA Substance Registry System: N-(4-methylbenzyl)-N-propargyl-1H-indole-2-carboxamide(1250829-43-6)

Safety Data

• Hazardous Substances Data: 1250829-43-6(Hazardous Substances Data)

Upstream product

• 1477-50-5 Indole-2-carboxylic acid 
• 892594-94-4 N-(4-methylbenzyl)prop-2-yn-1-amine 

Downstream Products

• 1250829-55-0 N-(4-methylbenzyl)-N-(propa-1,2-dienyl)-1H-indole-2-carboxamide 

Relevant articles and documents

Tunable Pd-catalyzed cyclization of indole-2-carboxylic acid allenamides: Carboamination vs microwave-assisted hydroamination

A variety of 3-vinyl-substituted imidazo[1,5-a]indole derivatives were synthesized by intramolecular Pd-catalyzed cyclization of the title allenamides through either a domino carbopalladation/exo-cyclization process or a novel hydroamination reaction that proceeds smoothly under microwave irradiation. Both the observed pathways involve a π-allyl-palladium(II) complex arising from insertion of the allene group into a palladium(II) species, the latter being formed in situ by the intervention of an aryl iodide or of the N-H group. In both cases, the role of nucleophile is covered by the indole nitrogen.