1250869-62-5Relevant articles and documents
Asymmetric organocatalytic tandem reaction to chiral pyrimidinone derivatives using urea as dinitrogen source
He, Zhao-Quan,Zhou, Quan,Wu, Li,Chena, Ying-Chun
supporting information; experimental part, p. 1904 - 1908 (2010/11/03)
A facile method for the asymmetric synthesis of pyrimidinone derivatives was developed via an organocatalytic tandem aza-Michael addition- hemiaminal formation-dehydroxylation reaction, using N,N′-dialkyloxyurea as dinitrogen source (up to 97% ee). The transformations of hemiaminal intermediates to pyrimidinones with more complex structures have been also investigated.