1251033-26-7

Basic information

• Product Name: 2-Bromo-5-chlorobenzo[d]oxazole
• Synonyms: 2-Bromo-5-chlorobenzo[d]oxazole
• CAS NO: 1251033-26-7
• Molecular Formula: C₇H₃BrClNO
• Molecular Weight: 232.46182
• Mol File: 1251033-26-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 302.6±34.0 °C(Predicted)
• Appearance: /
• Density: 1.820±0.06 g/cm3(Predicted)
• PKA: -1.40±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-5-chlorobenzo[d]oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-chlorobenzo[d]oxazole(1251033-26-7)
• EPA Substance Registry System: 2-Bromo-5-chlorobenzo[d]oxazole(1251033-26-7)

Safety Data

• Hazardous Substances Data: 1251033-26-7(Hazardous Substances Data)

Upstream product

• 17200-29-2 5-chloro-benzoxazole 
• 95-85-2 2-hydroxy-5-chloro-aniline 

Downstream Products

• 1144509-75-0 (2-((5-chloro-1,3-benzoxazol-2-yl)amino)ethyl)carbamic acid tert-butyl ester 
• 1373350-19-6 C₁₄H₁₂ClN₃O 
• 1373350-17-4 C₁₄H₁₁ClN₂O₂ 
• 1030377-33-3 Suvorexant 
• 1266975-27-2 5-chloro-2-[(5R)-hexahydro-5-methyl-1H-1,4-diazepin-1-yl]benzoxazole 
• 1383717-12-1 C₁₄H₂₀ClN₃O₄S 

Relevant articles and documents

Enantioselective synthesis of a dual orexin receptor antagonist

A concise, enantioselective synthesis of the potent dual orexin inhibitor suvorexant (1) is reported. Key features of the synthesis include a mild copper-catalyzed amination, a highly chemoselective conjugate addition, and a tandem enantioselective transamination/seven-membered ring annulation. The synthesis requires inexpensive starting materials and only four linear steps for completion.