125134-29-4

Basic information

• Product Name: (R)-5-Oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester
• CAS NO: 125134-29-4
• Molecular Weight: 319.357
• Mol File: 125134-29-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-5-Oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-Oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester(125134-29-4)
• EPA Substance Registry System: (R)-5-Oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester(125134-29-4)

Safety Data

• Hazardous Substances Data: 125134-29-4(Hazardous Substances Data)

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 1155-62-0 2-Benzyloxycarbonylamino-pentanedioic acid 
• 56-86-0 D-glutamic acid 
• 2937-50-0 Allyl chloroformate 

Downstream Products

• 125050-00-2 tert-butyl ester of D-glutamic acid semialdehyde oxime 
• 125050-16-0 N-(benzyloxy)amide of α-N-carbobenzoxy-δ-bromo-D-norvaline 
• 125049-95-8 α-N-carbobenzoxy-δ-N-(benzyloxy)-D-cycloornithine 
• 125050-18-2 tert-butyl ester of α-N-carbobenzoxy-δ-bromonorvaline 
• 125076-26-8 2-Benzyloxycarbonylamino-5-hydroxy-pentanoic acid tert-butyl ester 
• 125049-90-3 tert-butyl ester of α-N-carbobenzoxy-δ-N-(allyloxycarbonyl)-δ-N-(benzyloxy)-D-ornithine 
• 125050-09-1 5-[(E)-Benzyloxyimino]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 125049-97-0 α-carbo-tert-butoxy-α-carbobenzoxy-δ-O-(tert-butyldimethylsilyl)hydroxynorvaline tert-butyl ester 
• 125076-27-9 5-Acetoxy-2-benzyloxycarbonylamino-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 125049-94-7 5-(Allyl-benzyloxy-amino)-2-benzyloxycarbonylamino-pentanoic acid tert-butyl ester 
• 125050-05-7 tert-butyl ester of α-N-phthaloyl-γ-O-benzyl oxime of D-glutamic acid semialdehyde 
• 125049-98-1 α-N-carbo-tert-butoxy-α-N-carbobenzoxy-δ-hydroxy-D-norvaline tert-butyl ester 
• 125049-99-2 5-Benzyloxycarbonyloxy-2-tert-butoxycarbonylamino-pentanoic acid tert-butyl ester 
• 125049-93-6 tert-butyl ester of α-N-carbobenzoxy-δ-N-(benzyloxy)-D-ornithine 

Relevant articles and documents

1-Hydroxy-3-amino-2-piperidone (δ-N-Hydroxycycloornithine) Derivatives: Key Intermediates for the Synthesis of Hydroxamate-Based Siderophores

Several routes for the synthesis of δ-N-(benzyloxy)cycloornithine (2) from glutamic acid derived starting materials are described.Efficient methods were developed for the synthesis of glutamic acid γ-semialdehyde and γ-hydroxynorvaline derivatives as key substrates for the preparation of δ-N-hydroxyornithine analogues.Thus, the best approaches to the synthesis of 2 were: (1) reductive cyclization of an N-hydroxysuccinimide ester of the O-benzyloxime 4 of α-amino-protected glutamic acid γ-semialdehyde 5 and (2) cyclization of the N-(benzyloxy)amide of δ-bromonorvaline (7).