125142-16-7 Usage
Description
2,2-Dimethyl-butanoic Acid [1S-[1a,3a,4aa,7,8(2S,4S),8a]]-8-[2-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]tetrahydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,4,4a,7,8,8a-octahydro-4a-hydroxy-3,7-dimethyl-1-naphthalenyl Ester is a complex organic compound characterized by its unique molecular structure and chemical properties. It is a white solid with a specific stereochemistry, which is crucial for its potential applications.
Uses
Used in Pharmaceutical Industry:
2,2-Dimethyl-butanoic Acid [1S-[1a,3a,4aa,7,8(2S,4S),8a]]-8-[2-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]tetrahydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,4,4a,7,8,8a-octahydro-4a-hydroxy-3,7-dimethyl-1-naphthalenyl Ester is used as an intermediate for the preparation of Simvastatin hydroxymethyl metabolite, a key component in the synthesis of pharmaceuticals. Its role in the production process is essential for creating the final drug product, which can have therapeutic applications.
As an intermediate in the synthesis of Simvastatin hydroxymethyl metabolite, this compound plays a critical role in the development of pharmaceuticals that can potentially treat various health conditions. Its unique chemical properties and stereochemistry make it a valuable component in the creation of effective and targeted medications.
Check Digit Verification of cas no
The CAS Registry Mumber 125142-16-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,1,4 and 2 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 125142-16:
(8*1)+(7*2)+(6*5)+(5*1)+(4*4)+(3*2)+(2*1)+(1*6)=87
87 % 10 = 7
So 125142-16-7 is a valid CAS Registry Number.
InChI:InChI=1/C31H54O6Si/c1-11-30(7,8)28(33)36-25-16-20(2)19-31(34)15-14-21(3)24(27(25)31)13-12-22-17-23(18-26(32)35-22)37-38(9,10)29(4,5)6/h14-15,20-25,27,34H,11-13,16-19H2,1-10H3/t20-,21+,22-,23-,24+,25+,27+,31-/m1/s1
125142-16-7Relevant articles and documents
Synthesis of L-669,262, a Potent HMG-CoA Reductase Inhibitor
Stokker, Gerald E.
, p. 5983 - 5986 (2007/10/02)
Synthesis of L-669,262, isosimvastatin-3-one, has been achieved in seven steps from simvastatin (MK-733) and has been shown to be one of the most potent inhibitors of HMG-CoA reductase found to date.The synthesis of the 6-methyl homolog of simvastatin is also described.
Antihypercholesterolemic compounds
-
, (2008/06/13)
Compounds of Formula (I) and (II): STR1 are HMG-CoA reductase inhibitors.
Intermediates and processes for β-6-hydroxymethyl HMG-CoA reductable inhibitors
-
, (2008/06/13)
This invention discloses intermediates and a process for the preparation of 6-desmethyl-6-β-hydroxymethyl derivatives of lovastatin and analogs thereof at the 8-acyl side chain.