1251582-90-7

Basic information

• Product Name: C₁₃H₁₃BrN₂O₅
• Synonyms: C₁₃H₁₃BrN₂O₅
• CAS NO: 1251582-90-7
• Molecular Weight: 357.161
• Mol File: 1251582-90-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₃BrN₂O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₃BrN₂O₅(1251582-90-7)
• EPA Substance Registry System: C₁₃H₁₃BrN₂O₅(1251582-90-7)

Safety Data

• Hazardous Substances Data: 1251582-90-7(Hazardous Substances Data)

Upstream product

• 405224-23-9 5-bromo-2-chloropyridine-3-carbonitrile 

Relevant articles and documents

Nucleotide competing reverse transcriptase inhibitors: Discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors

A HTS screen led to the identification of a benzofurano[3,2-d]pyrimidin-2- one core structure which upon further optimization resulted in 1 as a potent HIV-1 nucleotide competing reverse transcriptase inhibitor (NcRTI). Investigation of the SAR at N-1 allowed significant improvements in potency and when combined with the incorporation of heterocycles at C-8 resulted in potent analogues not requiring a basic amine to achieve antiviral activity. Additional modifications at N-1 resulted in 33 which demonstrated excellent antiviral potency and improved physicochemical properties.

INHIBITORS OF HIV REPLICATION

Compounds of formula (I): wherein R1, R2, A1, A2, A3, A4, X and Y are as defined herein, are useful as inhibitors of HIV replication.