125207-39-8

Basic information

• Product Name: 2-(4-BROMOBUTYL)-5-NITRO-1H-ISOINDOLE-1,3(2H)-DIONE
• Synonyms: 2-(4-BROMOBUTYL)-5-NITRO-1H-ISOINDOLE-1,3(2H)-DIONE;N-(4-BROMOBUTYL)-4-NITROPHTHALIMIDE;N-(4-Bromobut-1-yl)-4-nitrophthalimide;2-(4-Bromobut-1-yl)-5-nitro-1H-isoindole-1,3(2H)-dione, 2-(4-Bromobut-1-yl)-5-nitroisoindolin-1,3-dione;2-(4-BroMobutyl)-5-nitroisoindoline-1,3-dione
• CAS NO: 125207-39-8
• Molecular Formula: C12H11BrN2O4
• Molecular Weight: 327.13
• Mol File: 125207-39-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 102-104
• Boiling Point: 459.4°Cat760mmHg
• Flash Point: 231.6°C
• Appearance: /
• Density: 1.65g/cm³
• Vapor Pressure: 1.27E-08mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: 2-(4-BROMOBUTYL)-5-NITRO-1H-ISOINDOLE-1,3(2H)-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BROMOBUTYL)-5-NITRO-1H-ISOINDOLE-1,3(2H)-DIONE(125207-39-8)
• EPA Substance Registry System: 2-(4-BROMOBUTYL)-5-NITRO-1H-ISOINDOLE-1,3(2H)-DIONE(125207-39-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 125207-39-8(Hazardous Substances Data)

Usage

General Description

2-(4-Bromobutyl)-5-nitro-1H-isoindole-1,3(2H)-dione is a chemical compound with the molecular formula C12H12BrNO4. It is a yellow crystalline powder that is used in the synthesis of pharmaceuticals and organic compounds. 2-(4-BROMOBUTYL)-5-NITRO-1H-ISOINDOLE-1,3(2H)-DIONE contains a bromine atom, a nitro group, and a cyclic isoindole-1,3(2H)-dione ring structure. It is used as a building block in organic synthesis and has potential applications in the development of new drugs and materials. Additionally, its unique structure makes it an interesting target for chemical research and exploration of its potential properties and applications.

InChI:InChI=1/C12H11BrN2O4/c13-5-1-2-6-14-11(16)9-4-3-8(15(18)19)7-10(9)12(14)17/h3-4,7H,1-2,5-6H2

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 89-40-7 4-nitrophthalimide 
• 62168-25-6 1,1-dibromobutane 
• 136918-14-4 phthalimide 

Downstream Products

• 1428332-76-6 C₁₉H₁₉BrN₂O₄S 

Relevant articles and documents

A new series of N2-substituted-5-(p-toluenesulfonylamino)phthalimide analogues as α-glucosidase inhibitors

Several members of a new family of non-sugar-type α-glycosidase inhibitors, bearing a 5-(p-toluenesulfonylamino)phthalimide moiety and various substituent at the N2 position, were synthesized and their activities were investigated. The newly synthesized compounds displayed different inhibition profile towards yeast α-glycosidase and rat intestinal α-glycosidase. Almost all the compounds had strong inhibitory activities against yeast α-glycosidase. Regarding rat intestinal α-glycosidase, only analogs with N2-aromatic substituents displayed varying degrees of inhibitory activities on rat intestinal maltase and lactase and nearly all compounds showed no inhibition against rat intestinal α-amylase. Structure-activity relationship studies indicated that 5-(p- toluenesulfonylamino)phthalimide moiety is a favorable scaffold to exert the α-glucosidase inhibitory activity and substituents at the N2 position have considerable influence on the efficacy of the inhibition activities.

Central cholinergic agents. I. Potent acetylcholinesterase inhibitors, 2-[ω-[N-alkyl-N-(ω-phenylalkyl)amino]alkyl]-1H-isoindole-1,3(2H)-dion es, based on a new hypothesis of the enzyme's active site

It has been suggested that the active site of acetylcholinesterase contains a hydrophobic binding site (HBS-1), which is closely adjacent to both the anionic and the esteratic sites. In this paper, we assumed that there exists another hydrophobic binding site (HBS-2), some distance removed from the anionic site. On this assumption, a new working hypothesis was proposed for the design of acetylcholinesterase inhibitors. A series of 2-[ω-[N-alkyl-N-(ω-phenylalkyl)amino]alkyl]-1H-isoindole-1,3(2H)-dion es was designed based on this hypothesis and tested for its inhibitory activities on acetylcholinesterase. Some in this series were revealed to be more potent than physostigmine. Optimum activity was found to be associated with a five carbon chain length separating the benzylamino group from the 1H-isoindole-1,3(2H)-dione (phthalimide) moiety. Quantitative study of substitution effect on the phthalimide moiety revealed that hydrophilic and electron-withdrawing groups enhance the activity.