125216-92-4Relevant articles and documents
Synthesis of substituted cinnamic acids and cinnamonitriles via palladium catalyzed coupling reactions of aryl halides with acrylic acid and acrylonitrile in aqueous media
Bumagin, N. A.,More, P. G.,Beletskaya, I. P.
, p. 397 - 402 (2007/10/02)
The palladium-catalysed coupling reactions of aryl halides with acrylic acid and acrylonitrile in the presence of a base (NaHCO3 or K2CO3) in water provide a novel and efficient and very simple method for the synthesis of substituted cinnamic acids and cinnamonitriles in high yields.NaHCO3 or K2CO3 effectively acts as a base in the reaction at elevated temperature (80-100 deg C).The reaction can be carried out with higher velocity and at low temperature (50-60 deg C), using CH3COOK as a base.
