125226-80-4

Basic information

• Product Name: (1R,5S,6S,7S)-(+)-6-acetoxymethyl-7-hydroxy-2-oxabicyclo<3.3.0>octan-3-one
• Synonyms: (1R,5S,6S,7S)-(+)-6-acetoxymethyl-7-hydroxy-2-oxabicyclo<3.3.0>octan-3-one
• CAS NO: 125226-80-4
• Molecular Weight: 214.218
• Mol File: 125226-80-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1R,5S,6S,7S)-(+)-6-acetoxymethyl-7-hydroxy-2-oxabicyclo<3.3.0>octan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,5S,6S,7S)-(+)-6-acetoxymethyl-7-hydroxy-2-oxabicyclo<3.3.0>octan-3-one(125226-80-4)
• EPA Substance Registry System: (1R,5S,6S,7S)-(+)-6-acetoxymethyl-7-hydroxy-2-oxabicyclo<3.3.0>octan-3-one(125226-80-4)

Safety Data

• Hazardous Substances Data: 125226-80-4(Hazardous Substances Data)

Upstream product

• 90529-18-3 (1SR, 5RS, 6RS, 7RS)-7-acetoxy-6-acetoxymethyl-2-oxabicyclo<3.3.0>octan-3-one 
• 108-05-4 vinyl acetate 
• 54423-47-1 (+/-)-(3aα,4α,5β,6aα)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopentafuran-2-one 

Relevant articles and documents

Enzymes in Organic Synthesis, 8: Synthesis of Enantiomerically Pure Prostaglandin Intermediates by Enzymatic Transesterification of (1S*,5R*,6R*,7R*)-(+/-)-7-Hydroxy-6-hydroxymethyl-2-oxabicyclooctan-3-one

Lipase Amano PS is a suitable biocatalyst for the highly regio- and enantioselective transesterification of the racemic prostaglandin building block (1S*,5R*,6R*,7R*)-(+/-)-7-hydroxy-6-hydroxymethyl-2-oxabicyclooctan-3-one (rac-1) yielding (1S,5R,6R,7R)-(-)-6-acetoxymethyl-7-hydroxy-2-oxabicyclooctan-3-one (2) and the unreacted (1R,5S,6S,7S)-(+)-enantiomer ent-1.Key Words: Prostaglandin intermediates / Enzymatic transformations / Lipases in organic solvents