1252614-16-6

Basic information

• Product Name: (-)-(S)-5-[(S)-hydroxy(4-methoxyphenyl)methyl]furan-2(5H)-one
• CAS NO: 1252614-16-6
• Molecular Weight: 220.225
• Mol File: 1252614-16-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (-)-(S)-5-[(S)-hydroxy(4-methoxyphenyl)methyl]furan-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(S)-5-[(S)-hydroxy(4-methoxyphenyl)methyl]furan-2(5H)-one(1252614-16-6)
• EPA Substance Registry System: (-)-(S)-5-[(S)-hydroxy(4-methoxyphenyl)methyl]furan-2(5H)-one(1252614-16-6)

Safety Data

• Hazardous Substances Data: 1252614-16-6(Hazardous Substances Data)

Upstream product

• 497-23-4 2-buten-4-olide 
• 123-11-5 4-methoxy-benzaldehyde 
• 121896-38-6 2-tert-butyldimethylsilyloxyfuran 

Relevant articles and documents

Squaramide-Sulfonamide Organocatalyst for Asymmetric Direct Vinylogous Aldol Reactions

Asymmetric direct vinylogous aldol reactions of furan-2(5H)-one with aldehydes in the presence of a catalytic amount of novel squaramide-sulfonamide organocatalyst resulted in the corresponding addition products with high to excellent enantioselectivities. This is the first successful report illustrating an example of highly stereoselective reactions using a squaramide-sulfonamide organocatalyst.

Catalytic, asymmetric vinylogous Mukaiyama aldol reactions of pyrrole- and furan-based dienoxy silanes: How the diene heteroatom impacts stereocontrol

Denmark's chiral bisphosphoramide/silicon tetrachloride system performs as an excellent Lewis base-Lewis acid catalyst for the vinylogous Mukaiyama aldol reaction of pyrrole- and furan-based dienoxy silanes with aromatic and heteroaromatic aldehydes. This asymmetric methodology provides a powerful synthetic entry to a variety of d-hydroxylated g-butenolide-type frameworks with high efficiency and valuable margins of regio-, diastereo-, and enantioselectivity. Notably, the nature of the heteroatom within the vinylogous dienoxy silane donor heavily impacts the diastereocontrol, with syn-configured aldol adducts emerging from pyrroles bearing electron- withdrawing N-protecting groups (Boc, Ts, and Cbz) and anti-configured adducts prevailing when furan- or N-alkyl/alkenylpyrrole donors are involved.