125265-52-3Relevant articles and documents
INTRAMOLECULAR DOUBLE MICHAEL REACTION III, STEREOSELECTIVE CHIRAL SYNTHESIS OF ATISIRAN-15-ONE
Ihara, Masataka,Toyota, Masahiro,Fukumoto, Keiichiro,Kametani, Tetsuji
, p. 1537 - 1540 (1985)
Atisiran-15-one (5) was stereoselectively synthesized starting from the ketone (10) through the intramolecular double Michael reaction.
An Enantioselective Total Synthesis of (+)-Atisirene by Intramolecular Double Michael Reaction
Ihara, Masataka,Toyota, Masahiro,Fukumoto, Keiichiro,Kametani, Tetsuji
, p. 2151 - 2162 (2007/10/02)
1,6-Conjugate addition of 2-methoxybenzylmagnesium bromide to 4-methylene-3,5,5-trimethylcyclohex-2-enone (7), followed by hydrocyanation, gave (+/-)-(1RS,2SR)-2--1,3,3-trimethyl-5-oxocyclohexanecarbonitrile (9), which was conver