1252883-90-1 Usage
Description
N-((3S,4S)-1-benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine, also known as Tofacitinib impurity P, is an enantiopure stereoisomer of the drug Tofacitinib (T528000). It is an impurity found in the Janus kinase 3 (Jak3) inhibitor, CP-690,550, which has been shown to inhibit selected members of the STE7 and STE20 subfamily of kinases. N-((3S,4S)-1-benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine plays a significant role in the pharmaceutical industry due to its potential applications and interactions with various biological targets.
Uses
Used in Pharmaceutical Industry:
N-((3S,4S)-1-benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine is used as an impurity in the development and production of Tofacitinib, a Jak3 inhibitor. Its presence in the drug may affect the overall efficacy and safety profile of the medication. As a result, it is crucial to monitor and control the levels of this impurity during the manufacturing process to ensure the quality and effectiveness of the final product.
Used in Research and Development:
In the field of research and development, N-((3S,4S)-1-benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine serves as a valuable compound for studying the structure-activity relationships of Jak3 inhibitors. By investigating the interactions between this impurity and various biological targets, researchers can gain insights into the design and development of more potent and selective inhibitors for the treatment of various diseases, including autoimmune and inflammatory disorders.
Used in Quality Control and Regulatory Compliance:
N-((3S,4S)-1-benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine is also used in the quality control and regulatory compliance processes for pharmaceutical products. Its identification and quantification in the drug formulation are essential to ensure that the product meets the required safety and efficacy standards. This impurity serves as a critical parameter in the assessment of the overall quality of the drug and its compliance with regulatory guidelines.
Check Digit Verification of cas no
The CAS Registry Mumber 1252883-90-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,2,8,8 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1252883-90:
(9*1)+(8*2)+(7*5)+(6*2)+(5*8)+(4*8)+(3*3)+(2*9)+(1*0)=171
171 % 10 = 1
So 1252883-90-1 is a valid CAS Registry Number.
1252883-90-1Relevant articles and documents
Methyl-α-d-glucopyranoside as Green Ligand for Selective Copper-Catalyzed N-Arylation
Chen, Fengyang,Chen, Guoliang,Chen, Yuanguang,Du, Fangyu,Zhou, Qifan
, p. 4590 - 4600 (2019/12/11)
In the selective N-arylation of amines or azoles with aryl halidesa-, methyl-α-d-glucopyranoside (MG) was found to function as a green ligand of copper powder. In addition, nitrogen heterocyclic amine compounds can also undergo the N-arylation coupling with heterocyclic aryl chlorides. This process allows access to a variety of aromatic amines and aryl azoles under mild reaction conditions, has good tolerance, and proceeds in moderate to high yield.
PIPERIDINE INHIBITORS OF JANUS KINASE 3
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Page/Page column 53, (2010/11/05)
The present invention relates to a new piperidine inhibitors of Janus Kinase 3 activity, pharmaceutical compositions thereof, and methods of use there-of.
