1253057-39-4

Basic information

• Product Name: (2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide
• Synonyms: (2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide
• CAS NO: 1253057-39-4
• Molecular Weight: 276.338
• Mol File: 1253057-39-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide(1253057-39-4)
• EPA Substance Registry System: (2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide(1253057-39-4)

Safety Data

• Hazardous Substances Data: 1253057-39-4(Hazardous Substances Data)

Upstream product

• 7570-49-2 5-amino-2-methylindole 
• 140-10-3 (E)-3-phenylacrylic acid 

Relevant articles and documents

Inhibition of monoamine oxidase by indole and benzofuran derivatives

Monoamine oxidase (MAO) is an important drug target for the treatment of neurological disorders. A series of indole and benzofuran derivatives were synthesised and evaluated as inhibitors of the two MAO isoforms, MAO-A and MAO-B. In general, the derivatives were found to be selective MAO-B inhibitors with Ki values in the nanoMolar (nM) to microMolar (μM) concentration range. The most potent MAO-B inhibitor, 3,4-dichloro-N-(2-methyl- 1H-indol-5-yl)benzamide, exhibited a Ki value of 0.03 μM and was 99 fold more selective for the B isoform. We conclude that these indole and benzofuran derivatives are promising reversible MAO-B inhibitors with a possible role in the treatment of neurodegenerative diseases such as Parkinson's disease (PD).