1253375-15-3

Basic information

• Product Name: 4-methyl-N-(3-(trifluoromethyl)phenyl)-N-vinylbenzenesulfonamide
• Synonyms: 4-methyl-N-(3-(trifluoromethyl)phenyl)-N-vinylbenzenesulfonamide
• CAS NO: 1253375-15-3
• Molecular Weight: 341.354
• Mol File: 1253375-15-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-methyl-N-(3-(trifluoromethyl)phenyl)-N-vinylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-(3-(trifluoromethyl)phenyl)-N-vinylbenzenesulfonamide(1253375-15-3)
• EPA Substance Registry System: 4-methyl-N-(3-(trifluoromethyl)phenyl)-N-vinylbenzenesulfonamide(1253375-15-3)

Safety Data

• Hazardous Substances Data: 1253375-15-3(Hazardous Substances Data)

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 106-93-4 ethylene dibromide 
• 98-59-9 p-toluenesulfonyl chloride 
• 108-05-4 vinyl acetate 
• 1584-58-3 WR₁₇₁₈₁₈ 

Relevant articles and documents

Enantioselective Synthesis of α-Aryl-β-Aminocyclopropane Carboxylic Acid Derivatives via Rh(II)-Catalyzed Cyclopropanation of Vinylsulfonamides with α-Aryldiazoesters

The reaction of vinylsulfonamides with donor–acceptor carbenes derived from α-aryldiazoesters, catalyzed by the tert-butyl glycine-derived dirhodium complex Rh2(S-4-Br-NTTL)4, has been reported. This method provides a variety of α-aryl-β-aminocyclopropane carboxylic acid derivatives bearing one quaternary carbon stereogenic center vicinal to the amino-substituted carbon in high yields with excellent diastereo- and enantioselectivities. Vinylsulfonamides showed complementary advantages over the well-developed vinylamides or vinylcarbamates for this Rh(II)-catalyzed cyclopropanation strategy. Moreover, these conformationally restricted α-aryl-β-aminocyclopropyl carboxylic acid derivatives can be readily incorporated into dipeptides.