125348-98-3Relevant articles and documents
Redox-Triggered α-C-H Functionalization of Pyrrolidines: Synthesis of Unsymmetrically 2,5-Disubstituted Pyrrolidines
Cheng, Yong-Feng,Rong, Hao-Jie,Yi, Cheng-Bo,Yao, Jun-Jun,Qu, Jin
, p. 4758 - 4761 (2015)
By using o-benzoquinone as an internal oxidant, the regio- and diastereoselective functionalization of the secondary over the tertiary α-C-H bond of 2-substituted pyrrolidines is first realized. Subsequent intermolecular addition of a nucleophile to the g
Intramolecular redox-triggered C-H functionalization
Jurberg, Igor D.,Peng, Bo,Woestefeld, Eckhard,Wasserloos, Maximilian,Maulide, Nuno
supporting information; experimental part, p. 1950 - 1953 (2012/04/04)
Sacrifice for the team: A one-pot method achieves remote functionalization at the α-position of an amine moiety through the sacrificial reduction of a neighboring group. The process takes advantage of an intramolecular redox reaction, thereby avoiding the need for any external oxidants. This method was applied to a concise five-step total synthesis of indolizidine 167B.
Heterocyclic compounds
-
, (2008/06/13)
Compounds are disclosed of formula (I) wherein Ra, R b, Rc and Rd represent hydrogen atoms or Ra and Rc together form a bond and Rb and Rd together form-CH=CH-CH=CH-;- represents a 5-membered (optionally containing an oxygen atom adjacent to the nitrogen)
