1253523-06-6

Basic information

• Product Name: (1R,2S,5S)-2-Isopropyl-5-methylcyclohexyl 2-(pyridin-3-yl)pyrrolidine-1-carboxylate
• Synonyms: (1R,2S,5S)-2-Isopropyl-5-methylcyclohexyl 2-(pyridin-3-yl)pyrrolidine-1-carboxylate
• CAS NO: 1253523-06-6
• Molecular Weight: 330.47
• Mol File: 1253523-06-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2S,5S)-2-Isopropyl-5-methylcyclohexyl 2-(pyridin-3-yl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,5S)-2-Isopropyl-5-methylcyclohexyl 2-(pyridin-3-yl)pyrrolidine-1-carboxylate(1253523-06-6)
• EPA Substance Registry System: (1R,2S,5S)-2-Isopropyl-5-methylcyclohexyl 2-(pyridin-3-yl)pyrrolidine-1-carboxylate(1253523-06-6)

Safety Data

• Hazardous Substances Data: 1253523-06-6(Hazardous Substances Data)

Upstream product

• 1253523-05-5 1-benzyl-3-bromo-5-(1-((((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)carbonyl)pyrrolidin-2-yl)pyridin-1-ium trifluoromethanesulfonate 

Downstream Products

• 22083-74-5 3-(1-methyl-pyrrolidin-2-yl)-pyridine 

Relevant articles and documents

One-pot formation of piperidine- and pyrrolidine-substituted pyridinium salts via addition of 5-alkylaminopenta-2,4-dienals to N-acyliminium ions: Application to the synthesis of (±)-nicotine and analogs

Addition of 5-alkylaminopenta-2,4-dienals onto N-acyliminium ions, generated in situ from α-hydroxycarbamates derived from pyrrolidine or piperidine, in the presence of zinc triflate, followed by dehydrative cyclization, allowed the formation of pyridinium salts substituted at their 3-position by a five- or six-membered nitrogen heterocycle. Subsequent N-dealkylation of the pyridinium moiety and deprotection of the secondary amine or reduction of the carbamate function led to (±)-nicotine and analogs.