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1253585-63-5

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1253585-63-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1253585-63-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,3,5,8 and 5 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1253585-63:
(9*1)+(8*2)+(7*5)+(6*3)+(5*5)+(4*8)+(3*5)+(2*6)+(1*3)=165
165 % 10 = 5
So 1253585-63-5 is a valid CAS Registry Number.

1253585-63-5Downstream Products

1253585-63-5Relevant articles and documents

Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90)

Brasca, Maria Gabriella,Mantegani, Sergio,Amboldi, Nadia,Bindi, Simona,Caronni, Dannica,Casale, Elena,Ceccarelli, Walter,Colombo, Nicoletta,De Ponti, Anna,Donati, Daniele,Ermoli, Antonella,Fachin, Gabriele,Felder, Eduard R.,Ferguson, Ronald D.,Fiorelli, Claudio,Guanci, Marco,Isacchi, Antonella,Pesenti, Enrico,Polucci, Paolo,Riceputi, Laura,Sola, Francesco,Visco, Carlo,Zuccotto, Fabio,Fogliatto, Gianpaolo

, p. 7047 - 7063 (2013/11/06)

Novel small molecule inhibitors of heat shock protein 90 (Hsp90) were discovered with the help of a fragment based drug discovery approach (FBDD) and subsequent optimization with a combination of structure guided design, parallel synthesis and application of medicinal chemistry principles. These efforts led to the identification of compound 18 (NMS-E973), which displayed significant efficacy in a human ovarian A2780 xenograft tumor model, with a mechanism of action confirmed in vivo by typical modulation of known Hsp90 client proteins, and with a favorable pharmacokinetic and safety profile.

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