1253856-48-2

Basic information

• Product Name: (2S,5S)-2-((S)-1-benzyloxycarbonyl-pyrrolidin-3-ylcarbamoyl)-5-(4-trifluoromethyl-benzenesulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: (2S,5S)-2-((S)-1-benzyloxycarbonyl-pyrrolidin-3-ylcarbamoyl)-5-(4-trifluoromethyl-benzenesulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 1253856-48-2
• Molecular Weight: 655.692
• Mol File: 1253856-48-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,5S)-2-((S)-1-benzyloxycarbonyl-pyrrolidin-3-ylcarbamoyl)-5-(4-trifluoromethyl-benzenesulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5S)-2-((S)-1-benzyloxycarbonyl-pyrrolidin-3-ylcarbamoyl)-5-(4-trifluoromethyl-benzenesulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester(1253856-48-2)
• EPA Substance Registry System: (2S,5S)-2-((S)-1-benzyloxycarbonyl-pyrrolidin-3-ylcarbamoyl)-5-(4-trifluoromethyl-benzenesulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester(1253856-48-2)

Safety Data

• Hazardous Substances Data: 1253856-48-2(Hazardous Substances Data)

Upstream product

• 550378-39-7 (S)-benzyl 3-aminopyrrolidine-1-carboxylate hydrochloride 
• 1253856-46-0 (2S,5S)-5-(4-trifluoromethyl-benzenesulfonyloxy)-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 

Downstream Products

• 1253856-50-6 (2S,5R)-5-benzyloxyamino(carboxylic acid tert-butyl ester)-2-((S)-1-benzyloxycarbonyl-pyrrolidin-3-ylcarbamoyI)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

PREPARATION OF ALKYL ESTERS OF N-PROTECTED OXO-AZACYCLOALKYLCARBOXYLIC ACIDS

A process for the preparation of alkyl esters of N-protected oxo-azacycloalkylcarboxylic acids of Formula III: comprises contacting a ketosulfoxonium ylide of Formula II: with an iridium catalyst to obtain Compound III, wherein PG1 is an amine protective group group; k is 0, 1, or 2; and RU, R1, R2, and R3 are defined herein. An embodiment of the process further com rises contacting a compound of Formula I: with a sulfoxonium halide of formula (RU)3S(O)Z, wherein Z is halide, in the presence of a strong base to obtain Compound II. Additional embodiments add a series of process steps leading to the synthesis of 7-oxo-1,6- diazabicyclo[3.2.1]octanes suitable for use as β-lactamase inhibitors.