1254036-84-4

Basic information

• Product Name: 4-[5-(bromomethyl)-2-oxazolyl]-6-chloro-1-(phenylsulfonyl)-1H-Indazole
• Synonyms: 4-[5-(bromomethyl)-2-oxazolyl]-6-chloro-1-(phenylsulfonyl)-1H-Indazole
• CAS NO: 1254036-84-4
• Molecular Weight: 452.716
• Mol File: 1254036-84-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4-[5-(bromomethyl)-2-oxazolyl]-6-chloro-1-(phenylsulfonyl)-1H-Indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[5-(bromomethyl)-2-oxazolyl]-6-chloro-1-(phenylsulfonyl)-1H-Indazole(1254036-84-4)
• EPA Substance Registry System: 4-[5-(bromomethyl)-2-oxazolyl]-6-chloro-1-(phenylsulfonyl)-1H-Indazole(1254036-84-4)

Safety Data

• Hazardous Substances Data: 1254036-84-4(Hazardous Substances Data)

Upstream product

• 1254036-82-2 methyl 2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate 
• 870606-29-4 5-chloro-3-iodo-2-methylaniline 
• 294190-16-2 2-iodo-4-chloro-6-nitrotoluene 
• 219312-44-4 5-chloro-2-methyl-3-nitro-aniline 
• 35572-79-3 5-chloro-2-methyl-1,3-dinitro-benzene 
• 606-20-2 2,6-dinitrotoluene 
• 1254036-80-0 6-chloro-1-(phenylsulfonyl)-4-(trimethylstannanyl)-1H-indazole 
• 1254036-94-6 6-chloro-4-iodo-1-(phenylsulfonyl)-1H-indazole 
• 885519-56-2 6-chloro-4-iodo-1H-indazole 
• 1254036-81-1 ethyl 2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate 
• 98-09-9 benzenesulfonyl chloride 
• 1254036-83-3 {2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazol-5-yl}methanol 

Downstream Products

• 1254036-85-5 6-chloro-4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole 
• 1361970-55-9 N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide 
• 1361970-34-4 N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide tosylate salt 
• 1361970-37-7 N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide mesitylenesulfonate salt 
• 1254036-91-3 6-chloro-4-(5-{[(2R,6R)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole 
• 1254036-68-4 N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide 
• 1254036-87-7 N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide 
• 1364799-92-7 C₇H₈O₃S*C₂₆H₂₈N₆O 
• 1364802-72-1 6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole 
• 1254036-86-6 6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole 

Relevant articles and documents

Application of C-H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib

This paper describes the development of an improved and scalable method for the manufacture of nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor. Incorporation of three consecutive catalytic reactions, including a palladium-catalyzed C-H functionalization and an iridium-catalyzed borylation, significantly simplified and shortened the synthetic sequence. The revised route was successfully implemented in a pilot plant on a multikilogram scale to deliver >100 kg of product.

Indazole derivatives for use in the treatment of influenza virus infection

The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.

Polymorphs and Salts

The present invention is directed to a polymorph of a compound and salts of a compound and polymorphs thereof, which compound is an inhibitor of kinase activity.