1254177-53-1Relevant articles and documents
A selective reduction 4 - nitrophenyl b nitrile and aldehyde condensation reaction product of
-
Paragraph 0059; 0060; 0061, (2017/08/04)
The invention discloses a method for selectively reducing a 4-nitrophenylacetonitrile/aldehyde condensation reaction product, which comprises the following steps: adding 4-nitrophenylacetonitrile, aldehyde, potassium carbonate and dihydropyridine ester into 2mL of water, heating to 60-100 DEG C, and stirring to react for 12-24 hours, wherein the mole ratio of the aldehyde to the 4-nitrophenylacetonitrile to the dihydropyridine is 1:1.2:1.2, and the mole ratio of the aldehyde to the potassium carbonate is 1:0.2-1:2; adding an organic solvent into the obtained solution in a volume ratio of 2:5 to extract at least three times; and merging the product organic layers, drying, distilling under reduced pressure, and carrying out column chromatography to obtain the reduction product. The method solves the problems of low economy and no environment friendliness when the organic solvent is used. The one-pot process simplifies the reaction steps, and can efficiently obtain the target product. By using the dihydropyridine ester as the hydrogen source, the method has the advantages of no toxicity, mild reaction conditions and high chemical selectivity.
Base-Promoted Cascade Approach for the Preparation of Reduced Knoevenagel Adducts Using Hantzsch Esters as Reducing Agent in Water
He, Tao,Shi, Ronghua,Gong, Yimou,Jiang, Guangyou,Liu, Ming,Qian, Shan,Wang, Zhouyu
supporting information, p. 1864 - 1869 (2016/07/16)
A cascade Knoevenagel condensation-reduction approach, which was carried out in water, has been reported. Using Hantzsch esters as reducing agent, under the promotion of base, a variety of reduced Knoevenagel adducts could be easily prepared by direct alkylation of malononitrile, ethyl 2-cyanoacetate, and 2-(4-nitrophenyl)acetonitrile, respectively. Meanwhile, a gram-scale synthesis of the protocol was also realized with excellent isolated yield.
Direct amino acid-catalyzed cascade reductive alkylation of arylacetonitriles: High-yielding synthesis of ibuprofen analogs
Ramachary, Dhevalapally B.,Shiva Prasad
scheme or table, p. 5246 - 5251 (2010/11/03)
A novel approach for a one-pot, three-component reductive alkylation (TCRA) reaction of arylacetonitriles-containing electron-withdrawing groups with aldehydes/ketones and 1,4-dihydropyridine via iminium-catalysis has been developed. Many TCRA reaction products have direct applications in agricultural and pharmaceutical chemistry.