1254475-87-0 Usage
Description
5-[3-(naphthalene-1-carbonyl)-1H-indol-1-yl]pentanoic acid is a complex organic compound with a unique molecular structure that features a pentanoic acid backbone, an indole ring, and a naphthalene-1-carbonyl group. 5-[3-(naphthalene-1-carbonyl)-1H-indol-1-yl]pentanoic acid is characterized by its potential biological activities and applications in various fields, particularly in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Applications:
5-[3-(naphthalene-1-carbonyl)-1H-indol-1-yl]pentanoic acid is used as a pharmaceutical compound for its potential therapeutic properties. The compound's unique structure allows it to interact with specific biological targets, such as receptors or enzymes, which may contribute to the development of new drugs for various medical conditions.
Used in Chemical Research:
In the field of chemical research, 5-[3-(naphthalene-1-carbonyl)-1H-indol-1-yl]pentanoic acid serves as a valuable compound for studying its chemical properties, reactivity, and potential applications in the synthesis of other complex molecules. Its unique structure makes it an interesting subject for exploring new chemical reactions and mechanisms.
Used in Drug Delivery Systems:
Similar to gallotannin, 5-[3-(naphthalene-1-carbonyl)-1H-indol-1-yl]pentanoic acid can be employed in the development of novel drug delivery systems. These systems aim to improve the compound's bioavailability, delivery, and therapeutic outcomes by utilizing various organic and metallic nanoparticles as carriers.
Used in Analytical Chemistry:
The compound's unique structure and properties make it a potential candidate for use in analytical chemistry, particularly in the development of new methods for the detection and quantification of biologically active molecules. Its interaction with specific targets can be exploited to create highly sensitive and selective analytical techniques.
Used in Material Science:
5-[3-(naphthalene-1-carbonyl)-1H-indol-1-yl]pentanoic acid may also find applications in material science, where its unique molecular structure could be utilized to develop new materials with specific properties, such as optical, electronic, or mechanical characteristics.
Check Digit Verification of cas no
The CAS Registry Mumber 1254475-87-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,4,4,7 and 5 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1254475-87:
(9*1)+(8*2)+(7*5)+(6*4)+(5*4)+(4*7)+(3*5)+(2*8)+(1*7)=170
170 % 10 = 0
So 1254475-87-0 is a valid CAS Registry Number.
1254475-87-0Relevant articles and documents
Peripherally selective cannabinoid 1 receptor (CB1R) agonists for the treatment of neuropathic pain
Seltzman, Herbert H.,Shiner, Craig,Hirt, Erin E.,Gilliam, Anne F.,Thomas, Brian F.,Maitra, Rangan,Snyder, Rod,Black, Sherry L.,Patel, Purvi R.,Mulpuri, Yatendra,Spigelman, Igor
, p. 7525 - 7543 (2016/09/04)
Alleviation of neuropathic pain by cannabinoids is limited by their central nervous system (CNS) side effects. Indole and indene compounds were engineered for high hCB1R affinity, peripheral selectivity, metabolic stability, and in vivo efficacy. An epithelial cell line assay identified candidates with 1% blood-brain barrier penetration for testing in a rat neuropathy induced by unilateral sciatic nerve entrapment (SNE). The SNE-induced mechanical allodynia was reversibly suppressed, partially or completely, after intraperitoneal or oral administration of several indenes. At doses that relieve neuropathy symptoms, the indenes completely lacked, while the brain-permeant CB1R agonist HU-210 (1) exhibited strong CNS side effects, in catalepsy, hypothermia, and motor incoordination assays. Pharmacokinetic findings of ～0.001 cerebrospinal fluid:plasma ratio further supported limited CNS penetration. Pretreatment with selective CB1R or CB2R blockers suggested mainly CB1R contribution to an indene's antiallodynic effects. Therefore, this class of CB1R agonists holds promise as a viable treatment for neuropathic pain.
