1254565-63-3

Basic information

• Product Name: propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide
• Synonyms: propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide
• CAS NO: 1254565-63-3
• Molecular Weight: 490.918
• Mol File: 1254565-63-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide(CAS DataBase Reference)
• NIST Chemistry Reference: propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide(1254565-63-3)
• EPA Substance Registry System: propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide(1254565-63-3)

Safety Data

• Hazardous Substances Data: 1254565-63-3(Hazardous Substances Data)

Upstream product

• 367-25-9 2,4-difluorophenylamine 
• 918523-45-2 2,6-difluoro-3-(propane-1-sulfonylamino)-benzoic acid benzyl ester 
• 1103234-56-5 2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid 
• 918523-44-1 3-amino-2,6-difluoro-benzoic acid benzyl ester 
• 1186194-32-0 2,6-difluoro-3-(propylsulfonamido)benzoyl chloride 
• 918504-27-5 N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]propane-1-sulfonamide 
• 444120-91-6 6-chloropyridin-3-ylboronic acid 

Relevant articles and documents

PYRROLO [2, 3. B] PYRIDINES WHICH INHIBIT RAF PROTEIN KINASE

Compounds (I) and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, and forms thereof are active on each of BRaf and c-Raf -1 protein kinase, and may also be active on either or both of A-Raf and B-Raf V600E protein kinase. Also described are methods of use thereof to treat diseases and conditions, including melanoma, colorectal cancer, thyroid cancer, ovarian cancer, and biliary tract cancer.