1254718-85-8

Basic information

• Product Name: (S)-tert-butyl 1-(4-nitro-3-(trifluoromethyl)phenylsulfonyl)pyrrolidine-2-carboxylate
• Synonyms: (S)-tert-butyl 1-(4-nitro-3-(trifluoromethyl)phenylsulfonyl)pyrrolidine-2-carboxylate
• CAS NO: 1254718-85-8
• Molecular Weight: 424.398
• Mol File: 1254718-85-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-tert-butyl 1-(4-nitro-3-(trifluoromethyl)phenylsulfonyl)pyrrolidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl 1-(4-nitro-3-(trifluoromethyl)phenylsulfonyl)pyrrolidine-2-carboxylate(1254718-85-8)
• EPA Substance Registry System: (S)-tert-butyl 1-(4-nitro-3-(trifluoromethyl)phenylsulfonyl)pyrrolidine-2-carboxylate(1254718-85-8)

Safety Data

• Hazardous Substances Data: 1254718-85-8(Hazardous Substances Data)

Upstream product

• 39234-83-8 4-nitro-3-(trifluoromethyl)-benzenesulfonyl chloride 
• 2812-46-6 proline tert-butyl ester 

Downstream Products

• 1254719-24-8 (R)-tert-butyl 2-(4-nitro-3-(trifluoromethyl)phenyl)pyrrolidine-2-carboxylate 

Relevant articles and documents

Enantioselective rearrangement of proline sulfonamides: An easy entry to enantiomerically pure α-aryl quaternary prolines

(Figure Presented) Enantiopure quaternary prolines have been prepared by stereoselective rearrangement of N-(arylsulfonyl)proline tert-butyl esters under basic conditions (see scheme), without any external source of stereochemical information. The sulfonamide aromatic ring must contain an electron-withdrawing group (EWG), which stabilizes an intermediate Meisenheimer complex. The overall process provides easy entry to a series of optically pure a-aromatic prolines.