1254758-50-3

Basic information

• Product Name: 2-chloro-5-[(2-propyl-1H-benzimidazol-1-yl)acetyl]benzenesulfonamide
• Synonyms: 2-chloro-5-[(2-propyl-1H-benzimidazol-1-yl)acetyl]benzenesulfonamide
• CAS NO: 1254758-50-3
• Molecular Weight: 391.878
• Mol File: 1254758-50-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-chloro-5-[(2-propyl-1H-benzimidazol-1-yl)acetyl]benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-[(2-propyl-1H-benzimidazol-1-yl)acetyl]benzenesulfonamide(1254758-50-3)
• EPA Substance Registry System: 2-chloro-5-[(2-propyl-1H-benzimidazol-1-yl)acetyl]benzenesulfonamide(1254758-50-3)

Safety Data

• Hazardous Substances Data: 1254758-50-3(Hazardous Substances Data)

Upstream product

• 5465-29-2 2-propyl-1H-benzimidazole 
• 59814-17-4 2-bromo-4'-chloro-3'-sulfamoyl-acetophenone 

Relevant articles and documents

Indapamide-like benzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, and XIII

A series of novel 2-chloro-5-[(1-benzimidazolyl- and 2- benzimidazolylsulfanyl)acetyl]benzene-sulfonamides were designed and synthesized. Their binding to recombinant human carbonic anhydrase (hCA) isozymes I, II, VII, and XIII was determined by isothermal titration calorimetry and thermal shift assay. The designed S-alkylated benzimidazole derivatives exhibited stronger binding than the indapamide-like N-alkylated benzimidazoles, with the Kdreaching about 50-100 nM with drug-targeted hCAs VII and XIII. The cocrystal structures of selected compounds with hCA II were determined by X-ray crystallography, and structural features of the binding event were revealed.