1255037-12-7

Basic information

• Product Name: (R)-2-nitro-3-phenylpropan-1-ol
• Synonyms: (R)-2-nitro-3-phenylpropan-1-ol
• CAS NO: 1255037-12-7
• Molecular Weight: 181.191
• Mol File: 1255037-12-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-nitro-3-phenylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-nitro-3-phenylpropan-1-ol(1255037-12-7)
• EPA Substance Registry System: (R)-2-nitro-3-phenylpropan-1-ol(1255037-12-7)

Safety Data

• Hazardous Substances Data: 1255037-12-7(Hazardous Substances Data)

Downstream Products

• 5267-64-1 (R)-2-amino-3-phenylpropanol 

Relevant articles and documents

Biocatalytic enantioselective approach to 3-aryl-2-nitropropanols: Synthesis of enantioenriched (R)-5-methoxy-3-aminochroman, a key precursor to the antidepressant drug Robalzotan

The results of our studies on the biocatalytic enantioselective synthesis of different 3-aryl-2-nitropropanols are presented. These compounds could be obtained in moderate to good ee both bybaker's yeast mediated reduction of (E)-2-nitro-3-arylprop-2-en-1-ol precursors and by lipase kinetic resolution of racemic 3-aryl-2-nitropropanols. The synthesis of enantioenriched (R)-5-methoxy-3-aminochroman is also achieved. This important moietyispresent in different molecules active toward the central nervous system and is also the precursor for the synthesis of Robalzotan (NAD299), a potent 5-HT1A antagonist.