1255188-82-9

Basic information

• Product Name: (R)-2-phenyl-2,5-dihydrothiophene-3-carbaldehyde
• Synonyms: (R)-2-phenyl-2,5-dihydrothiophene-3-carbaldehyde
• CAS NO: 1255188-82-9
• Molecular Weight: 190.266
• Mol File: 1255188-82-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-2-phenyl-2,5-dihydrothiophene-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-phenyl-2,5-dihydrothiophene-3-carbaldehyde(1255188-82-9)
• EPA Substance Registry System: (R)-2-phenyl-2,5-dihydrothiophene-3-carbaldehyde(1255188-82-9)

Safety Data

• Hazardous Substances Data: 1255188-82-9(Hazardous Substances Data)

Upstream product

• 40018-26-6 1,4-dithiane-2,5-diol 
• 104-55-2 3-phenyl-propenal 

Relevant articles and documents

Enzyme-Catalyzed Asymmetric Domino Thia-Michael/Aldol Condensation Using Pepsin

The novel catalytic promiscuity of pepsin from porcine gastric mucosa for the asymmetric catalysis of the domino thia-Michael/aldol condensation reaction in MeCN and buffer was discovered for the first time. Broad substrate specificity was tested, and a series of corresponding products were obtained with enantioselectivities of up to 84% ee. This specific catalysis was demonstrated by using recombinant pepsin and control experiments with denatured and inhibited pepsin. The reaction was also shown to occur in the active site by site-directed mutagenesis (the Asp32Ala mutant of pepsin), and a possible mechanism was proposed.