1255188-87-4Relevant articles and documents
An organocatalytic domino thia-michael/aldol condensation reaction: Highly enantioselective synthesis of functionalized dihydrothiophenes
Tang, Jie,Xu, Dan Qian,Xia, Ai Bao,Wang, Yi Feng,Jiang, Jun Rong,Luo, Shu Ping,Xu, Zhen Yuan
, p. 2121 - 2126 (2010)
An organocatalytic domino thia-Michael/ aldol condensation reaction of a, β-unsaturated aldehydes with 1, 4-dithiane-2,5-diol catalyzed by chiral diphenylprolinol TMS ether has been developed, which provides a new practical and direct route to chiral dihydrothiophenes with high yields (up to 90%) and excellent enantioselectivities (up to>99% ee). The catalytic mechanism of the domino reaction was further confirmed through the APCI-MS detection of proposed reaction intermediates.
