1255188-96-5 Usage
Description
(R)-2-(3-Chlorophenyl)-2,5-dihydrothiophene-3-carbaldehyde, commonly referred to as Carvedilol intermediate, is a vital chemical compound belonging to the thiophene family. It is characterized by the presence of a carbonyl group and a chlorine substituent on the phenyl ring, which contribute to its importance in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
(R)-2-(3-Chlorophenyl)-2,5-dihydrothiophene-3-carbaldehyde is used as a key intermediate in the synthesis of the drug Carvedilol. (R)-2-(3-Chlorophenyl)-2,5-dihydrothiophene-3-carbaldehyde is crucial for the production of Carvedilol, which is a medication used to treat heart failure and hypertension. Carvedilol functions as a non-selective beta blocker and also blocks alpha-1 receptors, providing beneficial effects on the heart and blood vessels. As a result, (R)-2-(3-Chlorophenyl)-2,5-dihydrothiophene-3-carbaldehyde plays a significant role in the development and manufacturing of a widely prescribed medication for cardiovascular health.
Check Digit Verification of cas no
The CAS Registry Mumber 1255188-96-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,5,1,8 and 8 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1255188-96:
(9*1)+(8*2)+(7*5)+(6*5)+(5*1)+(4*8)+(3*8)+(2*9)+(1*6)=175
175 % 10 = 5
So 1255188-96-5 is a valid CAS Registry Number.
1255188-96-5Relevant articles and documents
Enzyme-Catalyzed Asymmetric Domino Thia-Michael/Aldol Condensation Using Pepsin
Xiang, Yang,Song, Jian,Zhang, Yong,Yang, Da-Cheng,Guan, Zhi,He, Yan-Hong
, p. 6042 - 6048 (2016/07/26)
The novel catalytic promiscuity of pepsin from porcine gastric mucosa for the asymmetric catalysis of the domino thia-Michael/aldol condensation reaction in MeCN and buffer was discovered for the first time. Broad substrate specificity was tested, and a series of corresponding products were obtained with enantioselectivities of up to 84% ee. This specific catalysis was demonstrated by using recombinant pepsin and control experiments with denatured and inhibited pepsin. The reaction was also shown to occur in the active site by site-directed mutagenesis (the Asp32Ala mutant of pepsin), and a possible mechanism was proposed.