1255305-39-5Relevant articles and documents
Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952
Ikegashira, Kazutaka,Ikenogami, Taku,Yamasaki, Takayuki,Oka, Takahiro,Hase, Yasunori,Miyagawa, Naoki,Inagaki, Koji,Kawahara, Iichiro,Koga, Yoshihisa,Hashimoto, Hiromasa
, p. 873 - 877 (2019/02/13)
Optimization of novel azetidine compounds, which we had found as colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors, provided JTE-952 as a clinical candidate with high cellular activity (IC50 = 20 nM) and good pharmacokinetics pro