125553-69-7

Basic information

• Product Name: 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-nitrophenyl)propane-1,3-dione
• Synonyms: 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-nitrophenyl)propane-1,3-dione
• CAS NO: 125553-69-7
• Molecular Weight: 345.309
• Mol File: 125553-69-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-nitrophenyl)propane-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-nitrophenyl)propane-1,3-dione(125553-69-7)
• EPA Substance Registry System: 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-nitrophenyl)propane-1,3-dione(125553-69-7)

Safety Data

• Hazardous Substances Data: 125553-69-7(Hazardous Substances Data)

Upstream product

• 480-66-0 2,4,6-trihydroxyacetophenone 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 122-04-3 4-nitro-benzoyl chloride 
• 500-99-2 3,5-dimethoxyphenol 
• 62-23-7 4-nitro-benzoic acid 
• 125553-65-3 4',6'-dimethoxy-2'-(4-nitrobenzoyloxy)acetophenone 

Downstream Products

• 836608-01-6 2-(4-nitrophenyl)-5,7-dimethoxy-4H-chromen-4-one 
• 22812-39-1 2-(4-acetoxy-phenyl)-5,7-dimethoxy-chromen-4-one 
• 16290-50-9 3-(4-hydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one 
• 921942-45-2 2-(4-aminophenyl)-5,7-dimethoxy-4H-chromen-4-one 
• 437-64-9 genkwanin 

Relevant articles and documents

Synthesis and preliminary biological evaluation of chrysin derivatives as potential anticancer drugs

A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,4,6-trihydroxy- acetophenone, using modified Baker-Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.

Structural Studies on Bio-active Compounds. Part 12. Tautomerism and Conformation of Aryl-substituted 1-(2-Hydroxyphenyl)-3-phenylpropane-1,3-diones in the Solid Phase and in Solution

The tautomerism of a series of aryl-substituted 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-diones has been studied in deuteriochloroform solution by 1H n.m.r. techniques and, in the case of 1-(2-hydroxy-4-methoxyphenyl)-3-phenylpropane-1,3-dione and 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylpropane-1,3-dione, in the solid state by X-ray crystallography.Of these compounds, most exist between 80 and 95percent in the enolised form in solution and 1-(2-hydroxy-4-methoxyphenyl)-3-phenylpropane-1,3-dione adopts this tautomer in the crystal.However, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylpropane-1,3-dione is present as the diketone in the solid phase and enolises very slowly in solution. 1-(6-Benzoyloxy-2-hydroxyphenyl)-3-hydroxy-3-phenylprop-2-en-1-one is shown by 1H n.m.r. spectroscopy possibly to adopt a 'coiled' conformation in solution in deuteriochloroform.