1255647-37-0

Basic information

• Product Name: C₄₂H₆₀O₅
• CAS NO: 1255647-37-0
• Molecular Weight: 644.935
• Mol File: 1255647-37-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₂H₆₀O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₂H₆₀O₅(1255647-37-0)
• EPA Substance Registry System: C₄₂H₆₀O₅(1255647-37-0)

Safety Data

• Hazardous Substances Data: 1255647-37-0(Hazardous Substances Data)

Upstream product

• 18100-50-0 28-hydroxy-β-amyrone 
• 67852-85-1 glutaric acid chloride monobenzyl ester 
• 17990-42-0 Oleanonsaeure 
• 54322-10-0 glutaric acid monobenzyl ester 
• 508-02-1 Oleanolic acid 

Relevant articles and documents

Synthesis and biological evaluation of oleanolic acid derivatives as inhibitors of protein tyrosine phosphatase 1B

Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator in the process of insulin signaling and a promising drug target for diabetes and obesity. Derivatives of oleanolic acid were synthesized and evaluated as PTP1B inhibitors. Several derivatives exhibited moderate to good inhibitory activities against PTP1B, with 25f displaying the most promising inhibition (IC 50 = 3.12 μM). Structure-activity relationship analyses of these derivatives demonstrated that the integrity of the A ring and 12-ene moieties was important in the retention of PTP1B enzyme inhibitory activities. In addition, hydrophilic and acidic groups as well as the distance between the oleanene and acid moieties were associated with PTP1B inhibitory activities. Possible binding modes of 25f were explored by molecular docking simulations.