1255738-00-1

Basic information

• Product Name: O-2'-bromo-3'-methylpentanoyl-1-benzenesulfonylpyrrolidine-2-carboxamidoxime
• Synonyms: O-2'-bromo-3'-methylpentanoyl-1-benzenesulfonylpyrrolidine-2-carboxamidoxime
• CAS NO: 1255738-00-1
• Molecular Weight: 446.365
• Mol File: 1255738-00-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: O-2'-bromo-3'-methylpentanoyl-1-benzenesulfonylpyrrolidine-2-carboxamidoxime(CAS DataBase Reference)
• NIST Chemistry Reference: O-2'-bromo-3'-methylpentanoyl-1-benzenesulfonylpyrrolidine-2-carboxamidoxime(1255738-00-1)
• EPA Substance Registry System: O-2'-bromo-3'-methylpentanoyl-1-benzenesulfonylpyrrolidine-2-carboxamidoxime(1255738-00-1)

Safety Data

• Hazardous Substances Data: 1255738-00-1(Hazardous Substances Data)

Upstream product

• 147-85-3 L-proline 
• 98-09-9 benzenesulfonyl chloride 
• 72922-83-9 (S)‐1‐(phenylsulfonyl)pyrrolidine‐2‐carbonyl chloride 
• 88425-46-1 N-benzenesulfonyl-L-proline 
• 1175677-14-1 (2S)-N-Phenylsulfonyl-2-carbamoylpyrrolidine 
• 1198399-07-3 2-(S)-1-benzenesulfonylpyrrolidine-2-carbonitrile 
• 21582-41-2 (S)-2-bromo-3-methylpentanoic acid 
• 1255737-92-8 (2S)-N-phenylsulfonylpyrrolidin-2-carboxamidoxime 
• 1254975-35-3 C₆H₁₀BrClO 

Downstream Products

• 1254975-32-0 (2'S,5R)-5-sec-butyl-3-(1'-benzenesulfonylpyrrolidin-2'-yl)-4,5-dihydro-1,2,4-oxadiazin-6-one 

Relevant articles and documents

Synthesis, antibacterial and antifungal activities of new chiral 5-alkyl-3-(1′-benzenesulfonylpyrrolidin-2′-yl)-4,5-dihydro-1,2, 4-oxadiazin-6-ones

Chiral α-bromoacid chlorides can be easily prepared from amino acids. Their condensation with new 1-benzenesulfonylpyrrolidin-2-carboxamidoxime derived from proline lead to the corresponding O-(bromoacyl) amidoximes. The latter afforded new chiral 5-alkyl-3-(1′-benzenesulfonylpyrrolidin- 2′-yl)-4,5-dihydro-1,2,4oxadiazin-6-ones in good chemical yields via intramolecular cyclization in the presence of one equivalent of NaH. These new compounds were evaluated for their antibacterial and antifungal activities using micro-dilution tests against some strains of bacteria and fungi. Our compounds showed an excellent antibacterial activity, which is better than the drug levofloxacin.