1256096-35-1

Basic information

• Product Name: tert-butyl (R)-N-[2-(4-{[2-(6-tert-butoxycarbonylamino-2-pyridyl)acetyl]amino}phenyl)ethyl]-N-(2-hydroxy-2-phenylethyl)carbamate
• Synonyms: tert-butyl (R)-N-[2-(4-{[2-(6-tert-butoxycarbonylamino-2-pyridyl)acetyl]amino}phenyl)ethyl]-N-(2-hydroxy-2-phenylethyl)carbamate
• CAS NO: 1256096-35-1
• Molecular Weight: 590.72
• Mol File: 1256096-35-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (R)-N-[2-(4-{[2-(6-tert-butoxycarbonylamino-2-pyridyl)acetyl]amino}phenyl)ethyl]-N-(2-hydroxy-2-phenylethyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (R)-N-[2-(4-{[2-(6-tert-butoxycarbonylamino-2-pyridyl)acetyl]amino}phenyl)ethyl]-N-(2-hydroxy-2-phenylethyl)carbamate(1256096-35-1)
• EPA Substance Registry System: tert-butyl (R)-N-[2-(4-{[2-(6-tert-butoxycarbonylamino-2-pyridyl)acetyl]amino}phenyl)ethyl]-N-(2-hydroxy-2-phenylethyl)carbamate(1256096-35-1)

Safety Data

• Hazardous Substances Data: 1256096-35-1(Hazardous Substances Data)

Upstream product

• 408367-22-6 6-tert-butoxycarbonylamino-2-pyridylacetic acid 
• 223673-36-7 (R)-(4-aminophenylethyl)(2-hydroxy-2-phenylethyl)carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis and evaluation of novel phenylethanolamine derivatives containing acetanilides as potent and selective b 3-adrenergic receptor agonists

In the search for potent and selective human β3-adrenergic receptor (AR) agonists as potential pharmacotherapies for the treatment of obesity and non-insulin dependent (type II) diabetes, we prepared a novel series of phenylethanolamine derivatives containing acetanilides and evaluated their biological activities at the human β3-, β2-, and β1-ARs. Among these compounds, the 6-amino-2-pyridylacetanilide (36b), 2-amino-5- methylthiazol- 4-ylacetanilide (36g), and 5-amino-1,2,4-thiadiazol-3- ylacetanilide (36h) derivatives showed potent agonistic activity at the β3-AR with functional selectivity over the β1- and β2-ARs. In addition, these compounds exhibited significant hypoglycemic activity in a rodent diabetic model.