1256153-24-8

Basic information

• Product Name: 1-[(4-(4-bromophenyl)phenyl)]-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one
• CAS NO: 1256153-24-8
• Molecular Weight: 453.332
• Mol File: 1256153-24-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[(4-(4-bromophenyl)phenyl)]-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-(4-bromophenyl)phenyl)]-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one(1256153-24-8)
• EPA Substance Registry System: 1-[(4-(4-bromophenyl)phenyl)]-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one(1256153-24-8)

Safety Data

• Hazardous Substances Data: 1256153-24-8(Hazardous Substances Data)

Upstream product

• 4460-86-0 asaraldehyde 
• 5731-01-1 4-bromo-4'-acetylbiphenyl 

Relevant articles and documents

Reinvestigation of structure-activity relationship of methoxylated chalcones as antimalarials: Synthesis and evaluation of 2,4,5-trimethoxy substituted patterns as lead candidates derived from abundantly available natural β-asarone

We have examined the antimalarial structure-activity relationship of a series of methoxylated chalcones (A-CHCH-CO-B) against Plasmodium falciparum (3D7 strain) using fluorescence-based SYBR Green assay. Our study has revealed that electron releasing methoxy groups on ring A and electron withdrawing groups on ring B increases antimalarial potency while the positional interchange of these groups causes a decrease. In particular, 2,4,5-trimethoxy substitution pattern at ring A provided potent analogues which were easily derived from abundantly available natural β-asarone rich Acorus calamus oil. Cytotoxic evaluation indicated that the most active compounds 27 (IC50: 1.8 μM) and 26 (IC50: 2 μM) were also relatively non-toxic. Furthermore, compound 12 showed excellent resistance index of 1.1 against chloroquine resistant Dd2 strain of P. falciparum.