1256959-25-7

Basic information

• Product Name: benzyl 3-oxo-23-hydroxy-lup-20⁽²⁹⁾-en-28-oate
• Synonyms: benzyl 3-oxo-23-hydroxy-lup-20⁽²⁹⁾-en-28-oate
• CAS NO: 1256959-25-7
• Molecular Weight: 560.817
• Mol File: 1256959-25-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: benzyl 3-oxo-23-hydroxy-lup-20⁽²⁹⁾-en-28-oate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 3-oxo-23-hydroxy-lup-20⁽²⁹⁾-en-28-oate(1256959-25-7)
• EPA Substance Registry System: benzyl 3-oxo-23-hydroxy-lup-20⁽²⁹⁾-en-28-oate(1256959-25-7)

Safety Data

• Hazardous Substances Data: 1256959-25-7(Hazardous Substances Data)

Upstream product

• 1215746-83-0 benzyl 3,23-dihydroxy-lup-20⁽²⁹⁾-en-28-oate 
• 85999-40-2 23-hydroxybetulinic acid 
• 203576-71-0 benzyl (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-oxo-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylate 
• 192211-42-0 benzyl (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylate 
• 100-39-0 benzyl bromide 
• 472-15-1 Betulinic acid 
• 1256959-24-6 benzyl 3-hydroxyimino-23-hydroxy-lup-20⁽²⁹⁾-en-28-oate 
• 1256959-23-5 benzyl 3-acetoxyimino-23-acetoxy-lup-20⁽²⁹⁾-en-28-oate 
• 1256959-22-4 benzyl 3-hydroxyimino-lup-20⁽²⁹⁾-en-28-oate 

Downstream Products

• 85999-40-2 23-hydroxybetulinic acid 

Relevant articles and documents

Synthesis and Biological Evaluation of Oxygen-containing Heterocyclic Ring-fused 23-Hydroxybetulinic Acid Derivatives as Antitumor Agents

A collection of isoxazole and oxadiazole substituted 23-hydroxybetulinic acid (HBA) derivatives were designed, synthesized and evaluated for their antitumor activity. Most of the newly synthesized compounds exhibited more potent antiproliferative activity than patent compound 23-hydroxybetulinic acid, especially 13e and 14a were about four- to sevenfold more potent against all tested cancer cell lines than 23-hydroxybetulinic acid. Furthermore, the in vivo antitumor activity of 13e and 14a was validated in H22 liver cancer and B16 melanoma xenograft mouse models. The structure-activity relationships of these 23-hydroxybetulinic acid derivatives were also discussed based on the present investigation.

A partial synthesis of 23-hydroxybetulonic acid and 23-hydroxybetulinic acid starting from betulinic acid

A partial syntheses of the biologically active 23-hydroxybetulonic acid and 23-hydroxybetulinic acid starting from the naturally abundant betulinic acid has been developed in which the key step was the Baldwin's cyclopalladation of the 23-methyl group from a 3-one oxime of betulinic acid, an important drug in Chinese medicine.