1256962-88-5

Basic information

• Product Name: (4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine
• Synonyms: (4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine
• CAS NO: 1256962-88-5
• Molecular Weight: 416.461
• Mol File: 1256962-88-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine(1256962-88-5)
• EPA Substance Registry System: (4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine(1256962-88-5)

Safety Data

• Hazardous Substances Data: 1256962-88-5(Hazardous Substances Data)

Upstream product

• 677320-70-6 4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-2-methylsulfanyl-pyrimidine 
• 39856-50-3 5-bromo2-nitropyridine 
• 571189-16-7 4-(6-nitropyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 571188-59-5 tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 
• 1256963-15-1 4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-2-methanesulfonylpyrimidine 
• 775288-71-6 1-(6-nitropyridin-3-yl)piperazine 

Relevant articles and documents

4-(pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6

Identification and structure-guided optimization of a series of 4-(pyrazol-4-yl)-pyrimidines as selective CDK4/6 inhibitors is reported herein. Several potency and selectivity determinants were established based on the X-ray crystallographic analysis of representative compounds bound to monomeric CDK6. Significant selectivity for CDK4/6 over CDK1 and CDK2 was demonstrated with several compounds in both enzymatic and cellular assays.