125702-14-9Relevant articles and documents
Modular 1,1′-Ferrocenediyl-cored P-Stereogenic Diphosphines: ′′JDayPhos′′ Series and its Use in Rhodium(I)-Catalyzed Hydrogenation
Poklukar, Ga?per,Stephan, Michel,Mohar, Barbara
supporting information, p. 2566 - 2570 (2018/05/16)
A novel ferrocene-based P-stereogenic diphospine ligand series dubbed JDayPhos was developed, which rhodium(I) complexes of some of its members exhibited excellent enantioselectivity (up to >99% ee) and high activity in asymmetric hydrogenation of β-unsubstituted or -substituted itaconates and α-methylene-γ-oxo-carboxylates. (Figure presented.).
COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS
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Page/Page column 206, (2010/06/22)
The present invention is directed to novel compounds of formula (I) and their use in treating metabolic diseases.
Synthesis of versatile building blocks through asymmetric hydrogenation of functionalized itaconic acid mono-esters
Hekking, Koen F. W.,Lefort, Laurent,De Vries, Andre H. M.,Van Delft, Floris L.,Schoemaker, Hans E.,De Vries, Johannes G.,Rutjes, Floris P. J. T.
experimental part, p. 85 - 94 (2009/04/07)
The rhodium-catalyzed asymmetric hydrogenation of several β-substituted itaconic acid monoesters, using a library of monodentate phosphoramidite and phosphite ligands is described. Two β-alkylsubstituted substrates were readily hydrogenated by the rhodium complex Rh(COD) 2BF4 in combination with (S)-PipPhos as a ligand resulting in ees of 99 %. In contrast, the corresponding more hindered β-arylsubstituted substrates did not exhibit acceptable enantioselectivities under these conditions. However, the use of a 48-membered ligand library led to the identification of several suitable ligands for these substrates, resulting in ees of 89-99%. The resulting optically active succinic acid derivatives are potentially useful building blocks for more elaborate compounds, because of the ability to differentiate between the carboxylic acid and the ester groups on either side of the molecule.
