1257427-45-4

Basic information

• Product Name: 1-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]-3-(3-methoxyphenyl)-1H-pyrazole-5-carboxylic acid
• Synonyms: 1-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]-3-(3-methoxyphenyl)-1H-pyrazole-5-carboxylic acid
• CAS NO: 1257427-45-4
• Molecular Weight: 457.486
• Mol File: 1257427-45-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]-3-(3-methoxyphenyl)-1H-pyrazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]-3-(3-methoxyphenyl)-1H-pyrazole-5-carboxylic acid(1257427-45-4)
• EPA Substance Registry System: 1-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]-3-(3-methoxyphenyl)-1H-pyrazole-5-carboxylic acid(1257427-45-4)

Safety Data

• Hazardous Substances Data: 1257427-45-4(Hazardous Substances Data)

Upstream product

• 1316754-26-3 ethyl 3-(3-methoxyphenyl)-1H-pyrazole-5-carboxylate 
• 51997-51-4 4-(2,3-epoxypropoxy)carbazole 

Relevant articles and documents

Synthesis and cytotoxicity evaluation of 1-[3-(9H-carbazol-4-yloxy)-2- hydroxypropyl]-3-aryl-1H-pyrazole-5-carboxylic acid derivatives

Several novel molecules, 1-(3′-(9H-carbazol-4-yloxy)-2′- hydroxypropyl)-3-aryl-1H-pyrazole-5-carboxylic acid derivatives 3a-g were synthesized and screened to evaluate their cytotoxicity against cancer cells in vitro. The compounds 3a-g has been prepared by the reaction of ethyl 3-aryl-1H-pyrazole-5-carboxylate with 4-oxiranylmethoxy-9H-carbazole in moderate to excellent yields. The cytotoxicity of synthesized compounds was evaluated by a SRB (sulforhodamine B) assay against cancer cell such as SK-N-SH human neuroblastoma (NB), human A549 lung carcinoma, human breast cancer MCF-7 cell lines. The results showed that seven compounds can suppress SK-N-SH tumor cancer cell growth. Among them, compound 3d was the most effective small molecule in inhibiting SK-N-SH cell growth.