125762-03-0 Usage
Uses
Used in Pharmaceutical Industry:
(3R,4S)-1-[2-(dimethylamino)ethyl]-4-(4-methoxyphenyl)-2-oxo-6-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl acetate hydrochloride (1:1) is used as a pharmaceutical compound for its potential therapeutic effects. The presence of various functional groups in its structure may contribute to its biological activity and interactions with biological targets, making it a candidate for the development of new drugs.
Used in Research Applications:
(3R,4S)-1-[2-(dimethylamino)ethyl]-4-(4-methoxyphenyl)-2-oxo-6-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl acetate hydrochloride (1:1) is used as a research compound for studying its chemical properties and potential applications. Its complex structure and functional groups make it an interesting subject for scientific investigation, which may lead to the discovery of new uses and insights into its behavior in various chemical and biological contexts.
Check Digit Verification of cas no
The CAS Registry Mumber 125762-03-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,7,6 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 125762-03:
(8*1)+(7*2)+(6*5)+(5*7)+(4*6)+(3*2)+(2*0)+(1*3)=120
120 % 10 = 0
So 125762-03-0 is a valid CAS Registry Number.
125762-03-0Relevant articles and documents
Benzazepinone calcium channel blockers. 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones
Floyd,Kimball,Krapcho,Das,Turk,Moquin,Lago,Duff,Lee,White,Ridgewell,Moreland,Brittain,Normandin,Hedberg,Cucinotta
, p. 756 - 772 (2007/10/02)
As part of a program to discover potent antihypertensive analogues of diltiazem (3a), we prepared 1-benzazepin-2-ones (4). Benzazepinones competitively displace radiolabeled diltiazem, and show the same absolute stereochemical preferences at the calcium channel receptor protein. Derivatives of 4 containing a trifluoromethyl substituent in the fused aromatic ring show potent and long-acting antihypertensive activity. Studies of the metabolism of 4 lead to the metabolically stable antihypertensive calcium channel blockers 5a and 5c. Benzazepinone 5a is a longer acting and more potent antihypertensive agent than the second generation diltiazem analogue TA-3090 (3e).
