Cas 1257881-80-3,2-(3-(4-chlorophenoxy)benzyl)-N-(pyridin-3-yl)-2,9-diazaspiro[5.5]undecane-9-carboxamide

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Check Digit Verification of cas no

The CAS Registry Mumber 1257881-80-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,7,8,8 and 1 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1257881-80:
(9*1)+(8*2)+(7*5)+(6*7)+(5*8)+(4*8)+(3*1)+(2*8)+(1*0)=193
193 % 10 = 3
So 1257881-80-3 is a valid CAS Registry Number.

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1257881-80-3Relevant articles and documents

Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase

Keith, John M.,Jones, William M.,Pierce, Joan M.,Seierstad, Mark,Palmer, James A.,Webb, Michael,Karbarz, Mark J.,Scott, Brian P.,Wilson, Sandy J.,Luo, Lin,Wennerholm, Michelle L.,Chang, Leon,Brown, Sean M.,Rizzolio, Michele,Rynberg, Raymond,Chaplan, Sandra R.,Breitenbucher, J. Guy

, p. 737 - 741 (2014/02/14)

A series of mechanism based heteroaryl urea fatty acid amide hydrolase (FAAH) inhibitors with spirocyclic diamine cores is described. A potent member of this class, (37), was found to inhibit FAAH centrally, elevate the brain levels of three fatty acid ethanolamides [FAAs: anandamide (AEA), oleoyl ethanolamide (OEA) and palmitoyl ethanolamide (PEA)], and was moderately efficacious in a rat model of neuropathic pain.

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1257881-80-3