1257883-70-7

Basic information

• Product Name: 5-bromo-2-hydroxy-3-methyl-N-(quinolin-3-yl)benzamide
• Synonyms: 5-bromo-2-hydroxy-3-methyl-N-(quinolin-3-yl)benzamide
• CAS NO: 1257883-70-7
• Molecular Weight: 357.206
• Mol File: 1257883-70-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-bromo-2-hydroxy-3-methyl-N-(quinolin-3-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-hydroxy-3-methyl-N-(quinolin-3-yl)benzamide(1257883-70-7)
• EPA Substance Registry System: 5-bromo-2-hydroxy-3-methyl-N-(quinolin-3-yl)benzamide(1257883-70-7)

Safety Data

• Hazardous Substances Data: 1257883-70-7(Hazardous Substances Data)

Upstream product

• 580-17-6 3-aminoquinoline 
• 36194-82-8 5-bromo-2-hydroxy-3-methylbenzenecarboxylic acid 

Relevant articles and documents

Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical vein endothelial cells (HUVEC) in vitro. Compound 6 (5-chloro-2-hydroxy-N-(quinolin-8-yl)benzamide) exhibited the most potent inhibitory activity (IC50 = 3.8 and 5.5 nM for VEGFR-2 kinase and HUVEC, respectively). Docking simulation supported the initial pharmacophoric hypothesis and suggested a common mode of interaction at the ATP-binding site of VEGFR-2, which demonstrates that compound 6 is a potential agent for cancer therapy deserving further researching.