1257999-90-8

Basic information

• Product Name: C₂₁H₂₂F₂N₂O
• CAS NO: 1257999-90-8
• Molecular Weight: 356.415
• Mol File: 1257999-90-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₂F₂N₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₂F₂N₂O(1257999-90-8)
• EPA Substance Registry System: C₂₁H₂₂F₂N₂O(1257999-90-8)

Safety Data

• Hazardous Substances Data: 1257999-90-8(Hazardous Substances Data)

Upstream product

• 832710-65-3 2,8-diaza-spiro[4.5]decan-1-one hydrochloride 
• 27064-94-4 4,4'-difluorobenzhydryl chloride 

Relevant articles and documents

Design, syntheses, and SAR of 2,8-diazaspiro[4.5]decanones as T-type calcium channel antagonists

It was hypothesized that an appropriately substituted 2,8-diazaspiro[4.5] decan-1-one could effectively approximate a 5-feature T-type pharmacophore model published in the literature. Compounds were designed and synthesized to test our hypothesis and were found to be potent T-type calcium channel inhibitors with modest selectivity over L-type calcium channels. The synthesis and SAR of the series is described.